Week 9 update

It’s the end of week 9 and it’s certainly hard to believe how quickly the summer is passing. This research session has certainly had its ups and downs. The saponification/esterification sequence that previously plagued my chemical synthesis has become facile. My latest run had an overall yield of 71% over 3 steps, which is an improvement over the 65% yield that was achieved in the first generation synthesis. The following reduction, though, has proved difficult. After doing the reaction three times, I’ve maintained consistent results but the yields have been very low (20-30%).  it’s been a true test of using all available skills and techniques to learn how to improve a reaction. We’ve currently devised a new plan to circumvent the alcohol with a new scheme. Unfortunately, this new plan somewhat dampens the efforts and progress we made to get to that point, but it appears to be a necessary solution.