Yazdi Doshi Abstract

The thyroid hormone receptor (TR) is a member of the nuclear receptor superfamily that shuttles between the nucleus and the cytoplasm.[1] This nucleocytoplasmic movement is regulated by the nuclear envelope. Nuclear proteins cross the envelope via the nuclear pore complex (NPC).[2] In most cases, proteins must pass through the NPC by an energy dependent signal-mediated pathway. This process requires soluble factors known as karyopherins or importins which facilitate transport into the nucleus. Nuclear import and export of TR is highly regulated and has been shown to strongly modulate thyroid hormone responsive gene expression.[3] Determining the molecular mechanisms involved in the regulation of TR is crucial for understanding nuclear receptor function.

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