And so it begins

Proof that my research may be heading in the right direction. Here a female bluebird is about to deliver a spider to her hungry chicks at one of the houses I surveyed at.Proof that my research may be heading in the right direction. Here a female bluebird is about to deliver a spider to her hungry chicks at one of the houses I surveyed.

[Read more…]

1,5-Benzodiazepine Educational Synthesis – Update #1

Hello everybody,

I have made some progress with regards to my improvement upon the educational drug synthesis of a 1,5-Benzodiazepine, a structural precursor to benzodiazepine psychoactive drugs such as Valium and Xanax.  After discovering that my sulfamic acid catalyst was several years out of date (oops), I am now working with a fresh batch.  The sulfamic acid acts as an electron acceptor in the condensation reaction between ortho-Phenlenediamine and an excess of acetone, altogether known as an imine formation, which produces a structure containing stable carbon-nitrogen double bonds.  Without the sulfamic acid catalyst working to remove the water that is produced as a byproduct, the reaction proceeds at an agonizingly slow pace — definitely not completely under 30 minutes of stirring, which is why my yield has been almost nonexistent, up until now.

[Read more…]