Inflammation Pathways

My model had no inflammation pathways which I wanted to add as part of the developing features of Alzheimer’s Disease. Therefore, I added three to four reaction pathways that ultimately resulted in the inflammation of the cell. These pathways include the AGE/RAGE pathway which is activated when the AGE  protein and the RAGE protein come together to form a complex. This complex then results in the creation of reactive oxidative species (ROS). The activation of ROS then activates the NFkB pathways which ultimately results in the inflammation of the cell. Unfortunately, the model is currently not accessible to me therefore I can not further explain the reaction pathways in greater detail.

In addition to adding pathways to my model, I learned a little about MATLAB, which is a mathematical program used to show how the reaction pathways can affect the development of a disease. However, as I have yet to complete my model, I have not begun to use MATLAB. However, I plan to experiment with the program to better understand how to use it when the time comes.


  1. anwesterhaus says:

    All of your work sounds very fascinating especially since it sounds like the of the experiments you do are mainly done using computer modeling. As someone who doesn’t use much computer programming/modeling in my work, I am a little confused as to how this works. Could you explain in a little more detail how you can model these pathways to observe if cell inflammation results? Is there a special program that knows how all the pathways you use in your experiments works? Thanks and keep up the really interesting work!

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