Research Progress Update

Hello All!

We are now a few weeks in to the Summer 2018 research session and there are many developments I would like to relate.  After consultation with my lab mentor Dr. Shanta Hinton and lab alumnus Patrick Christian, I have added a computer-driven element to my project.  Using the Broad Institute’s open-source program CellProfiler, I have been able to characterize the effects of our protein of interest, MK-STYX, in thousands of different cells across more than a dozen different parameters.  This has helped further visualize MK-STYX’s impacts on autophagy factors like autophagosomes (cellular garbage trucks) and autolysosomes (cellular recycling centers).  Additionally, I have been utilizing the genetically refined BacMam virus to gain important insights into the inner workings of the cell.  This autophagy sensor lights up various points of interest and allows for them to be compared, counted, and analyzed across different experimental groups.  It has been an excellent time in lab so far, and with the help of Dr. Hinton and my brilliant lab mates, I expect to see many more intriguing research findings this summer.