A Computational Model of Progressive Multifocal Leukoencephalopathy (Update 3)

These past two weeks of research have been interesting, because rather than focusing on larger subtopics as in previous weeks, I was able to look at a greater number of smaller topics. I studied a wide range of transcription factors, including C/EBPB, Sp1, AP-1, YP1, Egr-1, SRSF-1, and NF-1. As Progressive Multifocal Leukoencephalopathy (PML) and the JC virus are still a relatively new discovery, some of these factors have limited research on them. Another problem I ran into was that some of these factors have been linked to the JC virus in literature, though the exact cellular mechanisms and interactions are unknown. Computational modeling directly relies on this knowledge, making my models for these factors less thorough than past transcription factors, like NFkB.

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