A Computational Model of Progressive Multifocal Leukoencephalopathy (Summary)

Over these past seven weeks of research, I’ve made so much progress on my models. More importantly,  I’ve learned a lot. I was able to study the JC virus infection cycle, how a variety of transcription factors affect viral replication and transcription, the body’s immune response, and potential PML treatments.

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July Update

For these past two weeks, I have been working to parse times of blinking traces in dyes R560 and RB. Blinking traces show intensity vs. time, following fluctuations in emissive intensities, and gives information regarding electron transfer kinetics. The purpose of parsing these traces is to separate early and late sections of the trace, and analyzing the statistical difference between the two. For R560, the dye’s structure does not change with excitation from the laser, so the blinking traces which show no difference when looking at the early versus the late components of the whole blinking trace. However, for RB, the dye undergoes dealkylation with excitation into R560, so the early and late components should demonstrate statistical difference.

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