A Computational Model of Progressive Multifocal Leukoencephalopathy (Summary)

Over these past seven weeks of research, I’ve made so much progress on my models. More importantly,  I’ve learned a lot. I was able to study the JC virus infection cycle, how a variety of transcription factors affect viral replication and transcription, the body’s immune response, and potential PML treatments.

I currently have seven completed models (attached below), though I will continue to reform and add to these during the fall semester. I look forward to beginning the computational portion of this project when I return to campus!

 

Models:

JC Virus Infection Cycle

JC Virus Infection Cycle

 

Tat protein

HIV protein Tat acts as a transcription factor

 

Transcription factor NFkB

Transcription factor NFkB

 

Transcription factor TGFB

Transcription factor TGFB

 

Transcription factors AP1 and NFAT4

Transcription factors AP1 and NFAT4

 

Comprehensive and simplified transcription factor model

Comprehensive and simplified transcription factor model

 

Immune response model

Immune response model