Closing Thoughts on My Summer Research Project

Hello There!

With my summer projects complete, and with an adequate time for reflection about my results and the future directions of my projects afforded, I now feel ready to complete my last post of the season.  From the data gathered from the autophagosome, lysosome, autolysosome, and L3CB experiments, I have seen first hand some of the fascinating cellular effects that MK-STYX exerts.  With this protein established as an important autophagy player in our in vitro studies, exciting new experimental directions beckon in other organismal models.  In the future, I will explore how autophagy transcription factors, the activators of specific genes in DNA, are influenced by MK-STYX.  Following this, I will investigate the known role MK-STYX plays in clearing misfolded proteins, or protein aggregates, from cells.  I believe this represents an important experimental direction as these variousprotein aggregate types are major factors in devastating diseases like Huntington’s Disease, ALS, and Alzheimer’s.

The past few months have afforded me a tremendous opportunity to grow as an aspiring scientist.  The support from the LLanso-Sherman Scholarship has been indispensable in helping me complete my experiments and contribute to the excellent science that the Hinton lab is known for.  My sincere thanks once again goes out to the Charles Center and the magnanimous individuals whose contributions make the summer research of William and Mary students both possible and productive.

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