Protein Modeling of Wild-type TRs and RTH mutants

To understand and explain localization of thyroid hormone receptors, I performed an ab initio folding of the primary sequences for both the wild-type and the mutant receptors. The mutant receptor demonstrated a potential conformational change. Therefore, I overlapped the two receptors together and create a predicted model how the wild-type receptor would conformationally shift to the mutant. The conformational change occurs within the DNA-Binding Domain, which could potentially affect the binding affinity between the receptor and the thyroid response elements. The following is selected times within the animation, which should the progressive conformational changes within the DBD.

Screen Shot 2019-07-30 at 10.33.02 AM

 

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