Hello There!
With my summer projects complete, and with an adequate time for reflection about my results and the future directions of my projects afforded, I now feel ready to complete my last post of the season. From the data gathered from the autophagosome, lysosome, autolysosome, and L3CB experiments, I have seen first hand some of the fascinating cellular effects that MK-STYX exerts. With this protein established as an important autophagy player in our in vitro studies, exciting new experimental directions beckon in other organismal models. In the future, I will explore how autophagy transcription factors, the activators of specific genes in DNA, are influenced by MK-STYX. Following this, I will investigate the known role MK-STYX plays in clearing misfolded proteins, or protein aggregates, from cells. I believe this represents an important experimental direction as these variousprotein aggregate types are major factors in devastating diseases like Huntington’s Disease, ALS, and Alzheimer’s.
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