Summary of Efforts toward a Loline Synthesis

This summer I have been attempting a total synthesis of the natural compound loline. The summer commenced with running familiar reactions at larger scales to move more material forward in the route. We were able to improve the yield of the RCM (ring closing metathesis) to an impressive 89%, but this was coupled with continually inconsistent results with the preceding acylation. I then ran three new reactions to make the methyl ester carbamate that was critical to our 2011 synthesis. After some initial troubleshooting, I was able to produce the desired product in good yield. Unfortunately, the following reduction with Dibal-H had a negligible yield despite several revisions to the reaction and work up conditions. There are about four remaining steps to loline past this point, so it would be a futile pursuit to continue running this reaction.

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Brief Summary of Summer Work

This summer my partner and I looked closely at one model of zooplankton population.  Using this model we found that the mortality was one of the most sensitive parameters which implied that it is one of the most sensitive parameters in other zooplankton population models.  This supported the claim that the mortality term need more research and refinement.  Some of the work we did was included in a proposal for a NSF grant to continue research on zooplankton modeling.  We also looked at different types of mortality terms that include predation and competition to limit the growth the population, but more work is need to find which is best, if any.

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These are findings

Leitner et al. (2008) describe five main aspects of spatiality that should be accounted for in any analysis of a social movement or instance contentious politics (e.g. resistance): place, scale, networks, positionality and mobility. In keeping with their wishes to avoid anointing a master frame, I shall take this opportunity to describe how each of these concepts have appeared in relation to the case and in particular, my guiding research question: how does the materiality of of coal fired power plants affect the spatial distribution of resistance?

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